Metabolic Markers Associated with Progression of Type 2 Diabetes Induced by High-Fat Diet and Single Low Dose Streptozotocin in Rats

Science is still searching for readily available, cost-effective biomarkers to assess metabolic disorders occurring before the onset and during development of type-2 diabetes (T2DM). The aim present study was induce T2DM in rats through a high-fat diet, followed by single administration low dose streptozotocin (STZ), make an assessment disease. were divided into two groups—experimental control—and monitored period 10 days. Changes anthropometric parameters, glucose, insulin, lipids, uric acid, advanced oxidation protein products (AOPP), as well histological changes liver pancreas, recorded. To insulin resistance, we used Homeostasis Model Assessment Insulin Resistance (HOMA-IR) beta cell function (HOMA-β) visceral obesity—adiposity index (AI). data demonstrate that increasing values HOMA-IR, AI, total cholesterol, triacylglycerols, low- very-low-density lipoproteins are important markers pre-diabetic state. stable hyperglycemia increased levels TC, TG, VLDL, LDL, acid AOPP experimental strongly suggest T2DM. HOMA-β, reliable criteria rats.